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Publications: Publications

Feature Publications

2024

Translational Potential 5 of Hypoxia-Inducible Factor-2α Signaling in Pulmonary Hypertension
Dai Z. Lung Biology and Pathophysiology [Book]. Chapter 5. 2024. DOI: 10.1201/9781003355243-6

2023

New Way to Study Pulmonary Hypertension in HFpEF
Dai Z, Thorp EB. Circ Res​. 2023 Nov 10;133(11):899-901. PMID: 37943948

E2F1 mediates SOX17 Deficiency Induces Pulmonary Hypertension

Yi D, Liu B, Ding H, Li S, Li R, Pan J, Ramirez K, Xia X, Kala M, Singh I, Ye Q, Lee WH, Frye R, Wang T, Zhao Y, Knox KS, Glembotski C, Fallon MB, Dai Z. Hypertension. 2023 Nov;80(11):2357-2371. PMID: 37737027.

The Role of a Lung Vascular Endothelium Enriched Gene TMEM100

Jiakai Pan, Bin Liu, Zhiyu Dai. Biomedicines. 2023.11(3), 937. PMID: 36979916

2022

Fatty Acid Metabolism in Endothelial Cell

Liu B, Dai Z. Fatty Acid Metabolism in Endothelial Cell. Genes. 2022 Dec 6;13(12):2301. PMID: 36553568

TMEM100, a Lung-Specific Endothelium Gene

Liu B, Yi D, Yu Z, Pan J, Ramirez K, Li S, Wang T, Glembotski CC, Fallon MB, Oh SP, Gu M, Kalucka J, Dai Z. TMEM100, a Lung-Specific Endothelium Gene. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022 Oct. PMID: 36252125.

Endothelial PHD2 Deficiency Induces Nitrative Stress via Suppression of Caveolin-1 in Pulmonary Hypertension

Liu B, Yi D, Dai J, Peng Y, Vanderpool R, Zhu MM, Dai Z.* & Zhao YY*. Endothelial PHD2 Deficiency Induces Nitrative Stress via Suppression of Caveolin-1 in Pulmonary Hypertension. (*Co-corresponding author). Eur Respir J. 2022 June. PMID:35798360

Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial Hypertension

Liu B, Yi, D, Pan JK, Dai J, Zhu MM, Zhao YY, Oh SP, Fallon MB, Dai Z. Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial Hypertension. Pulmonary Circulation. 2022;12:e12056. PMID: 35506101

2021

Loss of Endothelial HIF-Prolyl hydroxylase 2 (PHD2) Induces Cardiac Hypertrophy and Fibrosis

Dai Z*, Cheng J, Liu B, Yi D, Feng A, Wang T, Gao C, Wang Y, Zhu MM, Zhang X, Zhao YY*. Loss of Endothelial HIF-Prolyl hydroxylase 2 (PHD2) Induces Cardiac Hypertrophy and Fibrosis. J Am Heart Assoc.2021. Nov 16;10(22):e022077. (*Co-corresponding author). PMID: 34743552

Endothelial Cells in the Pathogenesis of Pulmonary Arterial Hypertension

Evans CE, Cober ND, Dai Z, Stewart DJ, Zhao YY. Endothelial Cells in the Pathogenesis of Pulmonary Arterial Hypertension. Eur Respir J. 2021. Jan. 28;2003957. PMID: 33509961.

Endothelial Autocrine Signaling through CXCL12/CXCR4/FoxM1 Axis Contributes to Severe Pulmonary Arterial Hypertension

This study identified a novel mechasnim of endothelial autocrine signaling regulating pulmonary vascular endothelial cell proliferation and pulmonary arterial hypertension. 

Yi D, Liu B, Wang T, Liao Q, Zhu MM, Zhao YY, Dai Z. Endothelial Autocrine Signaling through CXCL12/CXCR4/FoxM1 Axis Contributes to Severe Pulmonary Arterial Hypertension. Int. J. Mol. Sci. 2021, 22(6), 3182. PMID: 33804745.

before 2020

Editorial on the recent advances in the therapeutic potential of BRD4 inhibitors.

Dai Z, Zhao YY. BET in Pulmonary Arterial Hypertension: Exploration of BET Inhibitors to Reverse Vascular Remodeling. Am J Respir Crit Care Med. 2019; 200(7):806-808PMID: 31112388

Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in PAH with HIF-2α Inhibitor.

This is the first study demonstrating that pharmacologic inhibition of HIF-2a reverses severe PAH in three distinct PAH animal models.

Dai Z, Zhu MM, Peng Y, Machireddy N, Evans CE, Machado R, Zhang X, Zhao YY. Targeting severe pulmonary arterial hypertension with HIF-2α inhibitor. Am J Respir Crit Care Med. 2018;198(11):1423-1434. PMID: 29924941

Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension

This study identifies novel mechanisms of how endothelial cells and smooth smooth muscle cells cross-talk mediates severe pulmonary vascular remodeling and PAH.


Dai Z, Zhu MM, Peng Y, Machireddy N, Jin H, Zhang X, Zhao YY. Endothelial and Smooth Muscle Cells Interaction via FoxM1 Signaling Regulates Pulmonary Vascular Remodeling and Pulmonary Hypertension. Am J Respir Crit Care Med. 2018:198(6):788-802. PMID: 29664678 

Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α

This is the first study identifying a novel mouse model (Egln1Tie2Cre mice) with spontaneous severe PAH. Egln1Tie2Cre mice have high eleven right ventricular systolic pressure, right heart failure, severe occlusive vascular remodeling and plexiform-like lesions and progressive mortality.

Dai Z, Li M, Wharton J, Zhu MM, Zhao YY. Prolyl-4 hydroxylase 2 (PHD2) deficiency in endothelial cells and hematopoietic cells induces obliterative vascular remodeling and severe pulmonary arterial hypertension in mice and humans through hypoxia-inducible factor-2alpha.Circulation. 2016; 133: 2447-2458. PMID: 27143681

Endothelial p110gammaPI3K mediates endothelial regeneration and vascular repair after inflammatory vascular injury

Huang X*, Dai Z*, Cai L, Sun K, Cho J, Albertine KH, Malik AB, Schraufnagel DE, Zhao YY. Endothelial p110gammaPI3K mediates endothelial regeneration and vascular repair after inflammatory vascular injury. Circulation. 2016; 133: 1093-1103. (* Equal contribution) PMID: 26839042

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