Feature Publications
2024
General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2a/Notch4 Pathway
Liu B, Yi D, Xia X, Ramirez K, Zhao H, Cao Y, Dong R, Gao A, Ding H, Qiu S, Kalinichenko VV, Fallon MB, Dai Z. Circulation. 2024.
Translational Potential 5 of Hypoxia-Inducible Factor-2α Signaling in Pulmonary Hypertension
Dai Z. Lung Biology and Pathophysiology [Book]. Chapter 5. 2024. DOI: 10.1201/9781003355243-6
2023
New Way to Study Pulmonary Hypertension in HFpEF
Dai Z, Thorp EB. Circ Res​. 2023 Nov 10;133(11):899-901. PMID: 37943948
E2F1 mediates SOX17 Deficiency Induces Pulmonary Hypertension
Yi D, Liu B, Ding H, Li S, Li R, Pan J, Ramirez K, Xia X, Kala M, Singh I, Ye Q, Lee WH, Frye R, Wang T, Zhao Y, Knox KS, Glembotski C, Fallon MB, Dai Z. Hypertension. 2023 Nov;80(11):2357-2371. PMID: 37737027.
The Role of a Lung Vascular Endothelium Enriched Gene TMEM100
Jiakai Pan, Bin Liu, Zhiyu Dai. Biomedicines. 2023.11(3), 937. PMID: 36979916
2022
Fatty Acid Metabolism in Endothelial Cell
Liu B, Dai Z. Fatty Acid Metabolism in Endothelial Cell. Genes. 2022 Dec 6;13(12):2301. PMID: 36553568​
TMEM100, a Lung-Specific Endothelium Gene
Liu B, Yi D, Yu Z, Pan J, Ramirez K, Li S, Wang T, Glembotski CC, Fallon MB, Oh SP, Gu M, Kalucka J, Dai Z. TMEM100, a Lung-Specific Endothelium Gene. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022 Oct. PMID: 36252125.
Endothelial PHD2 Deficiency Induces Nitrative Stress via Suppression of Caveolin-1 in Pulmonary Hypertension
Liu B, Yi D, Dai J, Peng Y, Vanderpool R, Zhu MM, Dai Z.* & Zhao YY*. Endothelial PHD2 Deficiency Induces Nitrative Stress via Suppression of Caveolin-1 in Pulmonary Hypertension. (*Co-corresponding author). Eur Respir J. 2022 June. PMID:35798360
Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial Hypertension
Liu B, Yi, D, Pan JK, Dai J, Zhu MM, Zhao YY, Oh SP, Fallon MB, Dai Z. Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial Hypertension. Pulmonary Circulation. 2022;12:e12056. PMID: 35506101
2021
Loss of Endothelial HIF-Prolyl hydroxylase 2 (PHD2) Induces Cardiac Hypertrophy and Fibrosis
Dai Z*, Cheng J, Liu B, Yi D, Feng A, Wang T, Gao C, Wang Y, Zhu MM, Zhang X, Zhao YY*. Loss of Endothelial HIF-Prolyl hydroxylase 2 (PHD2) Induces Cardiac Hypertrophy and Fibrosis. J Am Heart Assoc.2021. Nov 16;10(22):e022077. (*Co-corresponding author). PMID: 34743552
Endothelial Cells in the Pathogenesis of Pulmonary Arterial Hypertension
Evans CE, Cober ND, Dai Z, Stewart DJ, Zhao YY. Endothelial Cells in the Pathogenesis of Pulmonary Arterial Hypertension. Eur Respir J. 2021. Jan. 28;2003957. PMID: 33509961.
Endothelial Autocrine Signaling through CXCL12/CXCR4/FoxM1 Axis Contributes to Severe Pulmonary Arterial Hypertension
This study identified a novel mechasnim of endothelial autocrine signaling regulating pulmonary vascular endothelial cell proliferation and pulmonary arterial hypertension.
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Yi D, Liu B, Wang T, Liao Q, Zhu MM, Zhao YY, Dai Z. Endothelial Autocrine Signaling through CXCL12/CXCR4/FoxM1 Axis Contributes to Severe Pulmonary Arterial Hypertension. Int. J. Mol. Sci. 2021, 22(6), 3182. PMID: 33804745.
before 2020
BET in Pulmonary Arterial Hypertension: Exploration of BET Inhibitors to Reverse Vascular Remodeling
Editorial on the recent advances in the therapeutic potential of BRD4 inhibitors.
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Dai Z, Zhao YY. BET in Pulmonary Arterial Hypertension: Exploration of BET Inhibitors to Reverse Vascular Remodeling. Am J Respir Crit Care Med. 2019; 200(7):806-808. PMID: 31112388
Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in PAH with HIF-2α Inhibitor.
This is the first study demonstrating that pharmacologic inhibition of HIF-2a reverses severe PAH in three distinct PAH animal models.
Dai Z, Zhu MM, Peng Y, Machireddy N, Evans CE, Machado R, Zhang X, Zhao YY. Targeting severe pulmonary arterial hypertension with HIF-2α inhibitor. Am J Respir Crit Care Med. 2018;198(11):1423-1434. PMID: 29924941
Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension
This study identifies novel mechanisms of how endothelial cells and smooth smooth muscle cells cross-talk mediates severe pulmonary vascular remodeling and PAH.
Dai Z, Zhu MM, Peng Y, Machireddy N, Jin H, Zhang X, Zhao YY. Endothelial and Smooth Muscle Cells Interaction via FoxM1 Signaling Regulates Pulmonary Vascular Remodeling and Pulmonary Hypertension. Am J Respir Crit Care Med. 2018:198(6):788-802. PMID: 29664678
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Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α
This is the first study identifying a novel mouse model (Egln1Tie2Cre mice) with spontaneous severe PAH. Egln1Tie2Cre mice have high eleven right ventricular systolic pressure, right heart failure, severe occlusive vascular remodeling and plexiform-like lesions and progressive mortality.
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Dai Z, Li M, Wharton J, Zhu MM, Zhao YY. Prolyl-4 hydroxylase 2 (PHD2) deficiency in endothelial cells and hematopoietic cells induces obliterative vascular remodeling and severe pulmonary arterial hypertension in mice and humans through hypoxia-inducible factor-2alpha.Circulation. 2016; 133: 2447-2458. PMID: 27143681
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Endothelial p110gammaPI3K mediates endothelial regeneration and vascular repair after inflammatory vascular injury
Huang X*, Dai Z*, Cai L, Sun K, Cho J, Albertine KH, Malik AB, Schraufnagel DE, Zhao YY. Endothelial p110gammaPI3K mediates endothelial regeneration and vascular repair after inflammatory vascular injury. Circulation. 2016; 133: 1093-1103. (* Equal contribution) PMID: 26839042
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